![]() Beta-blockers: If you're taking beta-blockers such as Lopressor (metoprolol) at the same time as metformin, the beta-blockers may prevent the fast heartbeat you typically feel when your blood sugar drops too low, virtually eliminating that warning sign.You may be asked to stop taking Glucophage 48 hours before receiving iodinated contrast for a diagnostic test. Radiological studies with contrast: Iodinated contrast materials, such as those used in computed tomography (CT) scans, combined with metformin can lead to a decrease in kidney function and lactic acidosis.When Glucophage is combined with supplements that target blood sugar, such as glymnema, blood sugar may drop too low. ![]() Anti-diabetes medications or supplements: When Glucophage is taken with Glynase (glyburide), it may decrease blood levels of glyburide.Breastfeeding: Metformin may enter breast milk, and there is a potential risk of low blood sugar in nursing infants.However, if you take metformin and are planning to become pregnant, you should discuss a plan for adjusting your diabetes treatment with your doctor. Pregnancy: Metformin has been used to treat gestational diabetes.Acute or chronic metabolic acidosis: Do not take Glucophage if you have metabolic acidosis, including diabetic ketoacidosis.Allergy or known hypersensitivity: Do not take Glucophage if you have a known sensitivity to metformin.History of heart attack, severe infection, or stroke: These all increase the risk of lactic acidosis.Do not take Glucophage if you have liver impairment due to an increased risk of lactic acidosis. Liver disease: Glucophage can decrease the liver's uptake of lactate, increasing lactate blood levels.This risk increases with the severity of kidney disease because metformin is excreted by the kidneys. Kidney disease or kidney failure: Do not take Glucophage if you have severe renal impairment, as the drug poses a risk of lactic acidosis.
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